![]() ![]() It has been shown to normalise prothrombin time in a trial of 12 healthy male subjects at a dose of 50 IU/kg (administered as a slow IV injection) (Eerenberg et al., 2011). ![]() For life-threatening bleeding or emergency surgery, consider the use of prothrombin complex concentrate (Prothrombinex®-VF) in consultation with haematology (risk of thrombotic complications).Idarucizumab: Reversing the effects of Dabigatran (CEC Factsheet, August 2016).aPTT >80 seconds or a dabigatran level >500 mg/mL.Consider dialysis in patients treated with dabigatran who have life-threatening bleeding and:.Give as 2 consecutive IV infusions of 2.5 g over 5–10 minutes each OR as 2 consecutive 2.5 g bolus injections Consider idarucizumab (Praxbind) - study dose: 5 g IV as a single dose (Pollack, 2015).Recombinant factor VIIa (NovoSeven® RT) is no longer recommended but other pro-haemostatic agents may be considered in consultation with haematology for life-threatening bleeding (significant risk of thrombotic complications).For ingestion within 2 hours: activated charcoal.Withhold further doses of anticoagulant.Send coagulation profile, including relevant levels (dabigatran level, aPTT, TT, prothrombin time and/or anti-Xa level).Organise urgent FBC, group and hold, creatinine. ![]() (2014) New oral anticoagulants: a practical guide on prescription, laboratory testing and peri-procedural / bleeding management, Internal Medicine Journal, vol.
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